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which causes more hypokalemia chlorlithalidone or hctz?

Answer

Chlorthalidone is associated with a higher risk of hypokalemia compared to hydrochlorothiazide
5
Abstract

5.

Comparison of clinical outcomes and safety associated with chlorthalidone vs hydrochlorothiazide in older adults with varying levels of kidney function

PubMed
High-impact

Chlorthalidone and hypokalemia

Hydrochlorothiazide and hypokalemia

In conclusion, while both chlorthalidone and hydrochlorothiazide can cause hypokalemia, chlorthalidone is associated with a higher risk. Therefore, careful monitoring of serum potassium levels is essential when initiating or adjusting doses of these medications, especially chlorthalidone. Potassium supplementation may be necessary in some cases to maintain serum potassium levels ≥ 4.0 mmol/L, particularly in patients with hypertension
4
Guidelines

4.

Patients with hypertension

Pathway
NCPCP 2000

References

1

Chlorthalidone

Drug

Chlorthalidone (Thalitone)

Pathway