Ask AI

Search

Updates

Loading...

Home

New Question

What is cirrhosis?

Answer

Cirrhosis is a chronic liver disease characterized by the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, leading to portal hypertension and end-stage liver disease
1
Abstract

1.

Liver cirrhosis

PubMed
Highly cited
.

Pathophysiology

Etiology

Cirrhosis can result from various causes, including:

Clinical progression

  • Compensated cirrhosis: The disease initially presents as asymptomatic (compensated cirrhosis).
  • Decompensated cirrhosis: It progresses to a symptomatic phase (decompensated cirrhosis), often resulting in hospitalization, impaired quality of life, and high mortality

Management

In summary, cirrhosis is a chronic liver disease characterized by fibrosis and regenerative nodule formation, leading to structural and functional impairment of the liver. It progresses from a compensated to a decompensated state, with significant clinical implications. Management involves addressing the underlying causes and complications, with liver transplantation as a potential option for advanced cases.

References

1

Lancet 2008

Abstract

Liver cirrhosis

PubMed
Highly cited