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what is abiraterone

Answer

Abiraterone acetate is an orally administered potent inhibitor of cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17), which is essential for the synthesis of testosterone from cholesterol
4
Abstract

4.

Abiraterone in prostate cancer: a new angle to an old problem

PubMed
High-impact
. It is used in the treatment of metastatic castration-resistant prostate cancer (mCRPC)

Mechanism of action

Clinical use

Efficacy

Adverse effects

In conclusion, abiraterone is an inhibitor of CYP17 used in the treatment of mCRPC, with demonstrated efficacy in improving overall and progression-free survival. However, its use is associated with certain adverse effects, including mineralocorticoid excess and cardiac disorders

References

1

Prostate cancer

Medical management

Guidelines

Management of castration-resistant prostate cancer, metastatic, hormonal therapy

Pathway
EANM/.../SIOG 2024