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What clinical repercussions does increased adipose tissue have on testosterone in men

Answer

Increased adipose tissue in men can have significant clinical repercussions on testosterone levels, leading to a condition known as hypogonadism. This condition is characterized by low testosterone levels and can manifest with various clinical symptoms and complications.

Clinical repercussions

Diagnostic investigations

  • Total testosterone measurement: Guidelines recommend obtaining a measurement of total testosterone in the morning (between 7 and 11 AM) and in the fasting state with a reliable laboratory assay for the evaluation of late-onset hypogonadism
  • Free testosterone measurement: In patients with conditions altering sex hormone-binding globulin and when total testosterone concentrations are in the borderline range (~8-12 nmol/L), it is recommended to measure or calculate free testosterone in addition to total testosterone
  • Sex hormone-binding globulin measurement: It is recommended to consider obtaining sex hormone-binding globulin and free testosterone calculation when indicated

Treatment considerations

In conclusion, increased adipose tissue in men can lead to hypogonadism, metabolic dysfunction, and osteoporosis, among other clinical repercussions. Diagnostic investigations and treatment considerations are crucial in managing these conditions.

References

1

Male hypogonadism

Diagnostic investigations

Guidelines

Testosterone levels

Pathway
EAA 2020