Ask AI

Search

Updates

Loading...

Home

New Question

risk factors, prognosis, pathophysiology, clinical manifestations of giant cell tumor of bone

Answer

Giant cell tumor of bone (GCTB) is a rare, benign, but locally aggressive bone neoplasm with a predilection for young adults. It is characterized by an abundance of osteoclastic giant cells induced by neoplastic mononuclear cells, which express high levels of receptor activator of nuclear factor κ-B ligand (RANKL)
4
Abstract

4.

Denosumab-treated giant cell tumor of bone exhibits morphologic overlap with malignant giant cell tumor of bone

PubMed
Highly cited
.

Risk factors

Prognosis

Pathophysiology

Clinical manifestations

In conclusion, GCTB is a rare, benign, but locally aggressive bone neoplasm with a predilection for young adults. It is characterized by specific genetic mutations and a unique cellular composition. The prognosis of GCTB is influenced by factors such as age, disease stage, and recurrence. The clinical manifestations of GCTB include pain, swelling, and limited range of motion, with radiographic findings of expansive lytic lesions.

References

1

J Bone Joint Surg Am 2015

Abstract

Risk factors for pulmonary metastases from giant cell tumor of bone

PubMed