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pathophysiology, prognosis and risk factors of brugada syndrome

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Brugada syndrome (BS) is a genetic disorder characterized by dysfunction of the cardiac sodium channels, particularly involving mutations in the SCN5A gene, which encodes the predominant cardiac sodium channel alpha subunit NaV1.5
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Disease

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Disease overview

Pathway
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Pathophysiology

Prognosis

Risk factors

In conclusion, BS is a genetic disorder characterized by dysfunction of cardiac sodium channels, primarily involving mutations in the SCN5A gene. The prognosis is variable, with a higher risk of future cardiac events in patients who have experienced aborted SCD or syncope. Risk factors include a family history of the syndrome, specific genetic mutations, and gender differences.

References

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Brugada syndrome

Disease

Disease overview

Pathway