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naltrexone for alcohol

Answer

Naltrexone is a medication used in the management of alcohol use disorder (AUD), with several guidelines recommending its use:

Indications

Contraindications

Dosage

Efficacy

Safety

  • Oral naltrexone (50 mg) and intramuscular naltrexone (380 mg) appear to be safe in patients with liver disease, including compensated cirrhosis, and may improve and prevent alcoholic liver disease

In conclusion, naltrexone is a recommended first-line treatment for alcohol use disorder, with demonstrated efficacy in reducing heavy drinking and improving abstinence. It is generally safe, including in patients with compensated liver disease, but should not be used in patients with acute hepatitis, liver failure, or those using opioids.

References

1

Alcohol use disorder

Medical management

Guidelines

Naltrexone

Pathway
CRISM 2023