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Most common cause of 1st trimester spontaneous miscarriage:

Answer

The most common cause of first trimester spontaneous miscarriage is chromosomal abnormalities, accounting for approximately 50-70% of early pregnancy losses.

Chromosomal abnormalities

Other causes

  • Other less common causes of first trimester miscarriage include maternal factors such as uterine abnormalities (e.g., septate uterus, fibroids), endocrine disorders (e.g., uncontrolled diabetes mellitus, thyroid disease), infections (e.g., cytomegalovirus, toxoplasmosis), and thrombophilic disorders (e.g., antiphospholipid syndrome).
  • Lifestyle factors such as smoking, excessive alcohol consumption, and illicit drug use can also contribute to the risk of miscarriage.

In conclusion, while there are several causes of first trimester spontaneous miscarriage, chromosomal abnormalities are the most common cause.

References

1

Genes (Basel) 2022

Abstract

Cytogenetic analysis of sporadic first-trimester miscarriage specimens using karyotyping and QF-PCR: a retrospective Romanian cohort study

PubMed