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Make me a mcq on gout and hyperuracimia pharmacotherapy ?

Answer

Multiple choice question

Which of the following is a first-line pharmacotherapy for gout and hyperuricemia?

A) Febuxostat

B) Probenecid

C) Allopurinol

D) Benzbromarone

Correct answer

C) Allopurinol

Explanation

  • Allopurinol is recommended as the first-line urate-lowering therapy for patients with gout, including those with chronic kidney disease (CKD) stage ≥ 3, according to the ACR 2020 guidelines
    .
  • The EULAR 2017 guidelines also recommend initiating allopurinol as first-line urate-lowering therapy in patients with normal kidney function
    .
  • The BSR 2017 guidelines suggest initiating allopurinol as first-line urate-lowering therapy at a low dose, with subsequent dose titration to target
    .
  • Febuxostat is considered an alternative second-line xanthine oxidase inhibitor in patients not tolerating allopurinol or if renal impairment prevents allopurinol dose escalation sufficient to achieve the therapeutic target
    .
  • Probenecid is recommended as the first choice among uricosurics for urate-lowering therapy monotherapy by the ACR 2012 guidelines, but it is not the first-line therapy overall
    .
  • Benzbromarone is considered in patients resistant to, or intolerant of, xanthine oxidase inhibitors, according to the BSR 2017 guidelines
    .

In conclusion, allopurinol is the first-line pharmacotherapy for gout and hyperuricemia, as recommended by multiple guidelines
.

References

1

Gout

Medical management

Guidelines

Treatment targets

Pathway
T2T 2017