- Acrodermatitis chronica atrophicans: For patients with acrodermatitis chronica atrophicans, the guidelines suggest administering oral antibiotic therapy for 21–28 days
Management of persistent symptoms
For patients with persistent or recurring nonspecific symptoms such as fatigue, pain, or cognitive impairment following recommended treatment for Lyme disease—but lacking objective evidence of reinfection or treatment failure—the AAN/ACR/IDSA 2021 guidelines recommend avoiding additional antibiotic therapy
In conclusion, the treatment for Lyme disease primarily involves antibiotic therapy tailored to the stage of the disease and the patient's clinical presentation. The management of persistent symptoms following treatment is a complex issue and an area of ongoing research.