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Ivabradine role in heart failure

Answer

Ivabradine plays a significant role in the management of heart failure, particularly in patients with reduced ejection fraction (HFrEF) and elevated heart rate.

Indications and guidelines

Clinical evidence

Dosage

In conclusion, ivabradine is an important therapeutic option for patients with HFrEF and elevated heart rate, particularly when β-blockers are ineffective or contraindicated. Supported by clinical trials like the SHIFT study and endorsed by major guidelines such as the ESC and ACC/AHA/HFSA, ivabradine has demonstrated efficacy in reducing heart failure hospitalizations and cardiovascular death. Proper patient selection and dosing are essential to maximize its therapeutic benefits.

References

1

Heart failure

Medical management

Guidelines

Ivabradine

Pathway
ESC 2021