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Is spironolactone good for treatment of diastolic heart failure?

Answer

Spironolactone, a mineralocorticoid receptor antagonist (MRA), has been studied for its efficacy in treating heart failure with preserved ejection fraction (HFpEF).

Efficacy in HFpEF

Other considerations

Complications and monitoring

In conclusion, while spironolactone has shown some potential benefits in HFpEF, its efficacy is more pronounced in patients at the lower end of the LVEF spectrum. Careful monitoring is required due to potential complications, and further studies are needed to fully understand its long-term safety and efficacy in this patient population.

References

1

Heart failure

Medical management

Guidelines

Aldosterone receptor antagonists

Pathway
ACC/.../HFSA 2022