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Explain the sporadic vs hereditary nature of Alzheimer’s disease?

Answer

Alzheimer's disease (AD) can be classified into two main types based on its genetic nature: sporadic and hereditary.

Sporadic Alzheimer's disease

Hereditary Alzheimer's disease

In conclusion, while both sporadic and hereditary forms of AD share common pathological features, they differ in terms of prevalence, age of onset, and genetic factors. The sporadic form is more common, typically presents later in life, and is influenced by a complex interplay of genetic and environmental factors. In contrast, the hereditary form is rare, presents earlier, and is caused by specific genetic mutations.

References

1

Lancet 2006

Abstract

Alzheimer's disease

PubMed
Highly cited