Dosage adjustment
- If additional glycemic control is required, the dose may be increased to 25 mg daily in patients who are tolerating empagliflozin
- The maximum recommended daily dose of empagliflozin is 25 mg per day
Special considerations
- Empagliflozin is not recommended for glycemic control in patients with an estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m²
- Empagliflozin is contraindicated in patients on dialysis
- Volume depletion should be corrected prior to initiation of empagliflozin
Administration
- Empagliflozin should be swallowed whole and should not be split, crushed, dissolved, or chewed
In conclusion, the initial dose of empagliflozin for type 2 diabetes mellitus is 10 mg daily, which can be increased to 25 mg daily for additional glycemic control. The drug should be taken in the morning, with or without food, and should be swallowed whole. Special considerations should be made for patients with renal impairment or volume depletion.