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Does hydrochlorothiazide cause gout

Answer

Hydrochlorothiazide, a thiazide diuretic, is associated with an increased risk of gout.

Mechanism

Evidence

Guidelines

In conclusion, hydrochlorothiazide is associated with an increased risk of gout, likely due to its effect on increasing serum urate levels. Clinical guidelines suggest considering alternative antihypertensive medications in patients with gout.

References

1

Gout

Specific circumstances

Guidelines

Patients taking antihypertensive medications

Pathway
ACR 2020