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Hydrochlorothiazide, a thiazide diuretic, is associated with an increased risk of gout.
4.
Global epidemiology of gout: prevalence, incidence and risk factors
3.
Diuretic use, increased serum urate levels, and risk of incident gout in a population-based study of adults with hypertension: the atherosclerosis risk in communities cohort study
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Use of diuretics and risk of incident gout: a population-based case-control study
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Patients taking antihypertensive medications
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In conclusion, hydrochlorothiazide is associated with an increased risk of gout, likely due to its effect on increasing serum urate levels. Clinical guidelines suggest considering alternative antihypertensive medications in patients with gout.
References
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Gout
Specific circumstances
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