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Diagnosis of NSIP

Answer

Nonspecific interstitial pneumonia (NSIP) is a distinct clinical entity among idiopathic interstitial pneumonias (IIPs), characterized by uniform involvement of the alveolar septa with interstitial inflammation and variable amounts of fibrosis
1
Abstract

1.

Nonspecific interstitial pneumonia and usual interstitial pneumonia with mutation in surfactant protein C in familial pulmonary fibrosis

PubMed
Highly cited
. The diagnosis of NSIP involves a combination of clinical, radiological, and histopathological findings.

Clinical presentation

Radiological findings

Histopathological findings

Differential diagnosis

Association with autoimmune disorders

In conclusion, the diagnosis of NSIP is based on a combination of clinical, radiological, and histopathological findings. It should be differentiated from other IIPs and interstitial lung diseases related to connective tissue diseases. Emerging evidence suggests a possible link between idiopathic NSIP and autoimmune disorders.

References

1

Mod Pathol 2004

Abstract

Nonspecific interstitial pneumonia and usual interstitial pneumonia with mutation in surfactant protein C in familial pulmonary fibrosis

PubMed
Highly cited