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definition, pathophysiology, clinical manifestations, risk factors and prognosis of adrenocortical carcinoma

Answer

Adrenocortical carcinoma (ACC) is a rare and aggressive neoplasm originating from the cortex of the adrenal gland
8
Abstract

8.

Adrenocortical carcinoma-towards genomics guided clinical care

PubMed
Highly cited
. It is characterized by a heterogeneous pathogenesis and often presents with an unfavorable prognosis
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Pathophysiology

Clinical manifestations

Risk factors

Prognosis

In conclusion, ACC is a rare and aggressive neoplasm with a heterogeneous pathogenesis and poor prognosis. It often presents with steroid hormone excess or abdominal mass effects, and a growing proportion of cases are diagnosed incidentally. Risk factors include a history of extra-adrenal malignancy and certain characteristics of adrenal incidentalomas. Prognosis is generally poor, with a high frequency of recurrence, and should be reassessed at each evaluation during follow-up to guide treatment strategy.

References

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Adrenocortical carcinoma

Classification and risk stratification

Guidelines

Prognosis

Pathway
ESE 2018