Ringer's Acetate vs. Normal Saline in Sepsis
Trial question
What is the role of Ringer's acetate solution in patients with sepsis?
Study design
Single center
Open label
RCT
Population
Characteristics of study participants
34.0% female
66.0% male
N = 116
116 patients (39 female, 77 male).
Inclusion criteria: adult patients diagnosed with sepsis.
Key exclusion criteria: only one kidney or a history of kidney transplantation; AKI due to pre-renal causes; primary renal disease; post-renal obstruction; HUS; TTP.
Interventions
N=73 Ringer's acetate solution (acetated Ringer's solution for resuscitation fluid).
N=43 normal saline solution (0.9% saline for resuscitation fluid).
Primary outcome
Rate of major adverse kidney events within 28 days
23.6%
27.3%
27.3 %
20.5 %
13.7 %
6.8 %
0.0 %
Ringer's acetate
solution
Normal saline
solution
No significant
difference ↔
No significant difference in the rate of major adverse kidney events within 28 days (23.6% vs. 27.3%; OR 0.8, 95% CI 0.4 to 1.9).
Secondary outcomes
No significant difference in the rate of new AKI in 5 days (58.3% vs. 56.8%; OR 1.1, 95% CI 0.5 to 2.3).
No significant difference in death at day 30 (26.1% vs. 35%; HR 0.7, 95% CI 0.3 to 1.5).
No significant difference in death at day 90 (33.8% vs. 37.5%; HR 0.9, 95% CI 0.4 to 1.9).
Conclusion
In adult patients diagnosed with sepsis, Ringer's acetate solution was not superior to normal saline solution with respect to the rate of major adverse kidney events within 28 days.
Reference
Jing Zhang, Fang Liu, Ziyi Wu et al. Acetate Ringer's Solution versus Normal Saline Solution in Sepsis: A Randomized, Controlled Trial. Shock. 2024 Apr 1;61(4):520-526.
Open reference URL