RVlob
Trial question
Is robotic-assisted lobectomy noninferior to video-assisted lobectomy in patients with resectable non-small cell lung cancer?
Study design
Single center
Open label
RCT
Population
Characteristics of study participants
51.0% female
49.0% male
N = 320
320 patients (163 female, 157 male).
Inclusion criteria: patients with resectable non-small cell lung cancer.
Key exclusion criteria: preoperative pathologically confirmed pulmonary tumors other than non-small-cell lung cancer; current or former comorbidity with other malignant tumors; receipt of any treatment for non-small-cell lung cancer before surgery; pleural dissemination detected during surgery; intraoperative change of surgical plan.
Interventions
N=157 robotic-assisted lobectomy (using a da Vinci® S™/Si™ surgical robot through 5 ports).
N=163 video-assisted lobectomy (performed through a 4-cm incision in the fifth intercostal space at the anterior axillary line).
Primary outcome
Overall survival at 3 years
94.6%
91.5%
94.6 %
70.9 %
47.3 %
23.6 %
0.0 %
Robotic-assisted
lobectomy
Video-assisted
lobectomy
Difference not exceeding
non-inferiority
margin ✓
Difference not exceeding non-inferiority margin in overall survival at 3 years (94.6% vs. 91.5%; HR 1.54, 95% CI 0.78 to 3.03).
Secondary outcomes
No significant difference in disease-free survival at 3 years (88.7% vs. 85.4%; HR 1.15, 95% CI 0.66 to 2).
Conclusion
In patients with resectable non-small cell lung cancer, robotic-assisted lobectomy was noninferior to video-assisted lobectomy with respect to overall survival at 3 years.
Reference
Zhenyi Niu, Yuqin Cao, Mingyuan Du et al. Robotic-assisted versus video-assisted lobectomy for resectable non-small-cell lung cancer: the RVlob randomized controlled trial. EClinicalMedicine. 2024 Jul 12:74:102707.
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