3D-TBP for Melanoma
Trial question
What is the role of 3D total body photography and sequential digital dermoscopy in patients at high risk of melanoma?
Study design
Single center
Open label
RCT
Population
Characteristics of study participants
62.0% female
38.0% male
N = 314
314 patients (194 female, 120 male).
Inclusion criteria: adult patients at high risk of melanoma.
Key exclusion criteria: current treatment for melanoma.
Interventions
N=158 total body photography (usual care plus 3D total body photography in person and sequential digital dermoscopy imaging via teledermatology every 6 months for 2 years).
N=156 usual care (usual care alone for 2 years).
Primary outcome
Completion of lesion excision for suspected melanoma
76.3%
52.6%
76.3 %
57.2 %
38.1 %
19.1 %
0.0 %
Total body
photography
Usual
care
Significant
increase ▲
NNT = 4
Significant increase in completion of lesion excision for suspected melanoma (76.3% vs. 52.6%; RR 1.46, 95% CI 1.32 to 1.62).
Secondary outcomes
Significant decrease in melanoma excision rate (2.03% vs. 3.62%; RR 0.56, 95% CI 0.34 to 0.92).
Significant increase in keratinocyte cancer excision rate (21.65% vs. 12.3%; RR 1.76, 95% CI 1.44 to 2.16).
Significant increase in benign lesion excision rate (52.86% vs. 36.48%; RR 1.45, 95% CI 1.28 to 1.64).
Conclusion
In adult patients at high risk of melanoma, total body photography was superior to usual care with respect to completion of lesion excision for suspected melanoma.
Reference
H Peter Soyer, Dilki Jayasinghe, Astrid J Rodriguez-Acevedo et al. 3D Total-Body Photography in Patients at High Risk for Melanoma: A Randomized Clinical Trial. JAMA Dermatol. 2025 May 1;161(5):472-481.
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