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Phentolamine

Class
Adrenergic receptor blockers
Subclass
Vasodilators
Generic name
Phentolamine mesylate
Brand names
Oraverse®
Dosage and administration
Adults patients
Restoration of function of anaesthetised soft tissue
•
0.1-0.8 mg submucosal once
Other off-label uses
•
Treatment of hypertension
Indications for use
Labeled indications
Adults
•
Restoration of function of anaesthetised soft tissue
Children
•
Symptomatic relief of soft tissue anesthesia
Off-label indications
Adults
•
Treatment of hypertension
Safety risks
Boxed warnings
Hypotension
•
Use extreme caution with pre-existing hypotension or those taking antihypertensive medications.
Contraindications
A known hypersensitivity to phentolamine
Severe hypotension or those who are in a state of shock
Unstable angina
Warnings and precautions
Tachycardia
•
Use caution with a history of cardiac arrhythmias.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Any modality
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Any severity
•
No guidance available.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B1
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals.
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
•
Bradycardia, facial edema, hypertension, diarrhea, dizziness, epigastric abdominal pain, generalized pruritus, headache, injection site pain, injection site reactions, nasal congestion, paresthesia, vomiting, skin tenderness, tachycardia
Unknown frequency
•
Cardiac arrhythmias, cerebrovascular accident, conjunctival injection, hypotension, myocardial infarction, orthostatic hypotension, pulmonary hypertension, asthenia, change in taste, chest pain, eye pain, nausea, palpitations, priapism, skin flushing
Interactions
Drug(s)
Check Interactions
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