Perampanel
Class
Anticonvulsants
Subclass
AMPA receptor antagonists
Substance name
Perampanel
Brand names
Fycompa®
Common formulations
Tablet
Dosage and administration
Adults patients
Treatment
Focal seizures
Adjunctive treatment
Adjunctive treatment for generalized tonic-clonic seizures
Indications for use
Labeled indications
Adults
Children
Safety risks
Boxed warnings
Behavioral disorders
Warnings and precautions
Drug abuse
Suicidal ideation
Specific populations
Renal impairment
eGFR 30-50 mL/min/1.73 m²
eGFR 10-30 mL/min/1.73 m²
eGFR < 10 mL/min/1.73 m²
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Child-Pugh A (mild)
Child-Pugh B (moderate)
Child-Pugh C (severe)
Pregnancy and breastfeeding
Pregnancy
All trimesters
Breastfeeding
Acceptable for use during breastfeeding.
Very low levels in breastfed infants (< 5%).
Unlikely to cause adverse effects in breastfed infants.
Adverse reactions
Very common > 10%
Common 1-10%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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