Pentobarbital

Class
Hypnotics and sedatives
Subclass
Barbiturates
Substance name
PENTobarbital
Common formulations
Solution for injection
Indications for use
Labeled indications
Adults
•
Treatment of insomnia
•
Treatment of seizures
Children
•
Treatment of insomnia (primary)
Pregnancy and breastfeeding
Breastfeeding
Consider alternative agents that may be safer.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
•
Somnolence
Uncommon < 1%
•
Agitation, angioedema, apnea, ataxia, bradycardia, central nervous system depression, drug-induced liver injury, exfoliative dermatitis, hypotension, megaloblastic anemia, neuropsychiatric disorder, anxiety, confusion, constipation, dizziness, fever, hallucinations, headache, hypoventilation, injection site reactions, insomnia, nausea, nervousness, nightmares, skin rash, slow thinking, syncope, vomiting, Stevens-Johnson syndrome
Unknown frequency
•
Dependence and withdrawal reactions, fixed drug eruption, myasthenia gravis, nystagmus, photosensitivity of skin, polyarteritis nodosa
Interactions
Drug(s)
Check Interactions
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