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Peginterferon beta-1a

Class
Cytokines
Subclass
Interferons
Substance name
Peginterferon beta-1a
Brand names
Plegridy®
Common formulations
Pre-filled injector
Safety risks
Contraindications
A history of hypersensitivity to natural or recombinant interferon beta or peginterferon
Warnings and precautions
Autoimmune disorders
•
Use caution with a history of autoimmune diseases.
Congestive HF
•
Use caution with a history of cardiac disease such as angina, cardiac arrhythmias, or myocardial infarction.
Drug-induced liver injury
•
Use caution with a history of hepatitis, hepatic disease, jaundice, or alcoholism.
Exacerbation of depression
•
Use caution with a history of depression, suicidal ideation, or other psychiatric disorders.
Hematologic disorder
•
Use caution with bone marrow suppression or who are receiving myelosuppressive therapy.
Seizures
•
Use caution with a history of seizure disorder.
Thrombotic microangiopathy
•
Use caution with underlying medical conditions or factors that predispose them to the development of Thrombotic microangiopathy (e.g; with autoimmune diseases).
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required. Monitor serum concentrations.
Renal replacement therapy
Continuous renal replacement
•
Use acceptable. No dose adjustment required.
Intermittent hemodialysis
•
Use acceptable. No dose adjustment required.
Peritoneal dialysis
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Any severity
•
Use with caution. Monitor serum aminotransferases. Monitor for toxicity.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: D
•
Avoid use. Evidence of fetal harm in humans. AU TGA pregnancy category: D.
Adverse reactions
Very common > 10%
•
Arthralgia, asthenia, fever, headache, injection site reactions, myalgia, pain, shivering
Common 1-10%
•
↓ WBC count, ↑ serum ALT, ↑ serum AST, ↑ serum gamma-glutamyltransferase, itching, nausea, skin rash, vomiting
Uncommon < 1%
•
↓ blood lymphocyte count, ↓ blood neutrophil count, ↓ platelet count, seizure
Rare < 0.1%
•
Anaphylaxis, ↓ platelet count, pancytopenia
Unknown frequency
•
Autoimmune hepatitis, acute liver failure, angioedema, congestive heart failure, hemolytic uremic syndrome, hepatitis, hyperthyroidism, hypothyroidism, injection site necrosis, depression, suicidal ideation, thrombotic microangiopathy
Interactions
Drug(s)
Check Interactions
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