Pegcetacoplan
Subcutaneous
Intravitreal
Class
Complement inhibitors
Subclass
Complement C3 inhibitors
Substance name
Pegcetacoplan
Brand names
Empaveli®, Syfovre®
Common formulations
Solution for injection
Dosage and administration
Adults patients
Treatment of paroxysmal nocturnal hemoglobinuria
Indications for use
Labeled indications
Adults
Safety risks
Boxed warnings
Encapsulated bacterial infections
Contraindications
Hypersensitivity to pegcetacoplan or its components
Warnings and precautions
Hemolysis
Infusion-related reactions
Prolonged PTT
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
Renal replacement therapy
Any modality
Hepatic impairment
Any severity
Pregnancy and breastfeeding
Pregnancy
All trimesters
Breastfeeding
Halt breastfeeding temporarily.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
Common 1-10%
Unknown frequency
Interactions
Drug(s)
Check Interactions
Reset
What did you think about this content?
Sign up for free to access the full drug resource