Paroxetine mesylate
Class
Antidepressants
Subclass
Selective serotonin reuptake inhibitors
Substance name
PARoxetine
Brand names
Pexeva®
Common formulations
Film-coated tablet
See also
Paroxetine hydrochloride CR (Paxil CR®)
Paroxetine hydrochloride (Paxil®)
Dosage and administration
Adults patients
Symptomatic relief
Chronic pruritus • Off-label
Pruritus in patients with cancer • Off-label
Treatment
Generalized anxiety disorder
Major depressive disorder
OCD
Panic disorder
PTSD
Social anxiety disorder
Vasomotor symptoms • Moderate-to-severe
Body dysmorphic disorder • Off-label
Premature ejaculation • Off-label
Premenstrual dysphoric disorder • Off-label
Indications for use
Labeled indications
Adults
Children
Off-label indications
Adults
Safety risks
Boxed warnings
Suicidal ideation
Contraindications
Hypersensitivity to paroxetine or its components
Concomitant use of MAOIs
Concomitant use of thioridazine or pimozide
Warnings and precautions
Acute angle-closure glaucoma
Akathisia, cognitive difficulties, motor impairment
Antidepressant discontinuation syndrome
Bleeding
Bone fracture
Decreased serum sodium
Decreased serum tamoxifen levels
Manic or mixed episodes
Seizure
Serotonin syndrome
Sexual dysfunction
Specific populations
Renal impairment
CrCl ≥ 30 mL/min
CrCl < 30 mL/min
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Child-Pugh A (mild)
Child-Pugh B (moderate)
Child-Pugh C (severe)
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: D
Breastfeeding
Use only if benefits outweigh potential risks.
Low levels in breastfed infants (5-25%).
May potentially cause adverse effects in breastfed infants.
Some adverse effects on lactation reported.
Adverse reactions
Very common > 10%
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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