Olezarsen
Class
Hypolipidemic agents
Subclass
Apolipoprotein C-III-directed antisense oligonucleotides
Substance name
Olezarsen
Brand names
Tryngolza®
Common formulations
Solution for injection
Indications for use
Labeled indications
Adults
Safety risks
Contraindications
Hypersensitivity to olezarsen or its components
Warnings and precautions
Drug hypersensitivity reaction
Specific populations
Renal impairment
eGFR ≥ 30 mL/min/1.73 m²
eGFR < 30 mL/min/1.73 m²
Renal replacement therapy
Any modality
Hepatic impairment
Child-Pugh A (mild)
Child-Pugh B (moderate)
Child-Pugh C (severe)
Pregnancy and breastfeeding
Pregnancy
All trimesters
Breastfeeding
Use only if benefits outweigh potential risks.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Unlikely to cause adverse effects in breastfed infants.
Adverse reactions
Very common > 10%
Common 1-10%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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