Ofloxacin
Oral
Ophthalmic
Otic
Class
Antibiotics
Subclass
Fluoroquinolones
Substance name
Ofloxacin
Brand names
Ocuflox®
Common formulations
Tablet
Dosage and administration
Adults patients
Treatment
Acute cystitis • Uncomplicated, caused by E. coli or K. pneumoniae
Acute cystitis • Uncomplicated, caused by Citrobacter diversus, Enterobacter aerogenes, P. aeruginosa, or P. mirabilis
Cervicitis • Caused by C. trachomatis
Cervicitis • Mixed infection caused by C. trachomatis and N. gonorrhoeae
Community-acquired pneumonia
COPD • Acute exacerbation
Non-gonococcal urethritis • Caused by C. trachomatis
Pelvic inflammatory disease
Prostatitis • Caused by E. coli
SSTIs • Uncomplicated
Urethritis • Mixed infection caused by C. trachomatis and N. gonorrhoeae
UTIs • Pyelonephritis or complicated UTI
Acute epididymitis • Off-label
Enteric fever • Off-label
Leprosy • Off-label
Plague • Off-label
Traveler's diarrhea • Off-label
Prevention
Plague • Post-exposure prophylaxis • Off-label
Plague • Pre-exposure prophylaxis • Off-label
Indications for use
Labeled indications
Adults
Off-label indications
Adults
Safety risks
Boxed warnings
Exacerbation of myasthenia gravis
Tendinitis, tendon rupture, peripheral neuropathy, CNS adverse events
Contraindications
Hypersensitivity to ofloxacin or its components or to other quinolones
QT prolongation
Uncorrected hypokalemia
Warnings and precautions
Antimicrobial resistance
C. difficile infection
Decreased blood glucose
Mask symptoms of syphilis
Photosensitivity of skin
Seizure
Specific populations
Renal impairment
CrCl > 50 mL/min
CrCl 20-50 mL/min
CrCl < 20 mL/min
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Any severity
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B3
Breastfeeding
Do not use during breastfeeding.
Unknown drug levels in breastfed infants.
May potentially cause adverse effects in breastfed infants.
Adverse reactions
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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