Metyrosine

Class
Adrenal hormones
Subclass
Amino acid derivatives
Substance name
metyroSINE
Common formulations
Capsule
Indications for use
Labeled indications
Adults
•
Treatment of pheochromocytoma
Children
•
Treatment of pheochromocytoma
Safety risks
Boxed warnings
Hypertensive crisis
•
Use extreme caution with pheochromocytoma.
Contraindications
Who have a known metyrosine hypersensitivity
Warnings and precautions
Nephrolithiasis
•
Use caution who are unable to maintain water/fluid intake.
Specific populations
Renal impairment
eGFR 20-50 mL/min/1.73 m²
•
Use with caution. Specific data in renal impairment are not available; use caution since metyrosine is extensively excreted by the kidney.
eGFR 10-20 mL/min/1.73 m²
•
Use with caution. Specific data in renal impairment are not available; use caution since metyrosine is extensively excreted by the kidney.
eGFR < 10 mL/min/1.73 m²
•
Use with caution. Specific data in renal impairment are not available; use caution since metyrosine is extensively excreted by the kidney.
Renal replacement therapy
Continuous renal replacement
•
Use with caution.
Intermittent hemodialysis
•
Use with caution.
Peritoneal dialysis
•
Use with caution.
Pregnancy and breastfeeding
Pregnancy
All trimesters
•
Use only if clearly needed. No adequate human or animal studies have been undertaken to assess adverse fetal effects.
•
The definitive treatment for pheochromocytoma is surgery, but in patients who are past 24 weeks gestation, problems with tumor accessibility may delay surgery.
•
Pretreatment with an α-blocker, such as phenoxybenzamine or doxazosin, is recommended prior to surgical removal of the tumor to reduce maternal and fetal mortality.
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
•
Extrapyramidal signs, diarrhea
Unknown frequency
•
Anemia, ↓ platelet count, disorientation, drug withdrawal syndrome, ↑ liver enzymes, lethargy, oculogyric crisis, peripheral edema, abdominal pain, anxiety, breast swelling, confusion, dry mouth, dysuria, erectile dysfunction, fatigue, galactorrhea, hallucinations, headache, hematuria, nasal congestion, nausea, vomiting, sedation, urticaria
Interactions
Drug(s)
Check Interactions
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