Methylcellulose

Class
Laxatives
Subclass
Bulk-forming laxatives
Substance name
Methylcellulose, methyl cellulose
Brand names
Citrucel®
Common formulations
Powder
Dosage and administration
Adults patients
Symptomatic relief of constipation
•
Start at: 1-2 g PO daily
•
Maintenance: 2-6 g PO daily, in 1-6 divided doses
•
Maximum: 6 g per day
Indications for use
Labeled indications
Adults
•
Symptomatic relief of constipation
Safety risks
Contraindications
Dysphagia
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Any modality
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Any severity
•
Use acceptable. No dose adjustment required.
Pregnancy and breastfeeding
Pregnancy
All trimesters
•
Generally acceptable for use.
Breastfeeding
Acceptable for use during breastfeeding.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
•
Bloating, flatulence
Uncommon < 1%
•
Bowel obstruction, itching, nausea, skin rash, vomiting
Interactions
Drug(s)
Check Interactions
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