Methenamine hippurate
Class
Urinary antiseptics
Subclass
Formaldehyde-releasing agents
Substance name
Methenamine hippurate, hexamethylenetetramine, hexamine
Brand names
Hiprex®
Common formulations
Tablet
Safety risks
Contraindications
Gout
Pre-existing renal impairment, renal failure, or severe dehydration
Warnings and precautions
Allergic reactions
Specific populations
Renal impairment
eGFR 20-50 mL/min/1.73 m²
eGFR 10-20 mL/min/1.73 m²
eGFR < 10 mL/min/1.73 m²
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Child-Pugh A (mild)
Child-Pugh B (moderate)
Child-Pugh C (severe)
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: A
Breastfeeding
Acceptable for use during breastfeeding.
Unknown drug levels in breastfed infants.
No overt adverse effects reported in breastfed infants.
Adverse reactions
Common 1-10%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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