Metaproterenol

Class
Bronchodilators
Subclass
Short-acting beta-agonists
Substance name
Metaproterenol
Common formulations
Syrup
Dosage and administration
Adults patients
Reversible airway obstruction in patients with asthma
•
20 mg PO q6-8h
Reversible airway obstruction in patients with COPD
•
20 mg PO q6-8h
Indications for use
Labeled indications
Adults
•
Symptomatic relief of reversible airway obstruction in patients with asthma
•
Symptomatic relief of reversible airway obstruction in patients with COPD
Safety risks
Boxed warnings
Cardiac arrhythmias
•
Use extreme caution with cardiovascular disorders.
Serotonin syndrome
•
Use extreme caution with concomitant MAOI therapy.
Contraindications
A seizure disorder
Diabetes mellitus
Thyroid disease
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Any modality
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Any severity
•
Use acceptable. No dose adjustment required.
Pregnancy and breastfeeding
Pregnancy
All trimesters
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals.
Breastfeeding
Acceptable for use during breastfeeding.
•
NOT MARKETED IN THE US.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
•
Tachycardia, tremor
Common 1-10%
•
Dizziness, fatigue, headache, nausea, palpitations
Uncommon < 1%
•
Diaphoresis, hypertension, myoclonus, blurred vision, chills, cough, dry mouth, dysgeusia, fever, generalized pruritus, muscle cramps, musculoskeletal pain, somnolence, syncope, vomiting
Unknown frequency
•
Abdominal distension, bronchospasm, ↓ serum potassium, exacerbation of arrhythmia, premature ventricular contractions, ↑QTc interval, hallucinations, insomnia, nervousness, paranoid ideation, shaking, skin flushing, stupor
Interactions
Drug(s)
Check Interactions
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