Losartan / hydrochlorothiazide
Class
Antihypertensives
Subclass
Angiotensin receptor blocker / thiazide combination
Generic name
Losartan / hydroCHLOROthiazide
Brand names
Hyzaar®
Contains
Hydrochlorothiazide
Losartan
Common formulations
Film-coated tablet
Dosage and administration
Adults patients
Treatment
Hypertension
Prevention
Prevention of stroke in patients with hypertensive LVH
Indications for use
Labeled indications
Adults
Safety risks
Boxed warnings
Fetal toxicity, neonatal morbidity and mortality
Contraindications
Hypersensitivity to losartan potassium/hydrochlorothiazide or any of its components
Anuria
Coadministration with aliskiren in patients with diabetes
Warnings and precautions
Acute angle-closure glaucoma, acute transient myopia
Exacerbation of SLE
Hypotension
Low urine output
Specific populations
Renal impairment
CrCl > 30 mL/min
CrCl 10-30 mL/min
CrCl < 10 mL/min
Renal replacement therapy
Any modality
Hepatic impairment
Any severity
Pregnancy and breastfeeding
Pregnancy
All trimesters
Breastfeeding
Consider alternative agents that may be safer.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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