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Fluticasone furoate

Intranasal
Inhalation
Class
Steroid hormones
Subclass
Glucocorticoids
Generic name
Fluticasone furoate
Brand names
Flonase Sensimist®
Common formulations
Nasal spray
See also
Fluticasone propionate (Armonair Digihaler®, Flovent HFA®, Flovent Diskus®, Xhance®)
Contained in
Fluticasone / vilanterol (Breo Ellipta®)
Dosage and administration
Adults patients
Treatment of allergic rhinitis • Seasonal or perennial
•
27.5 mcg IN daily
Indications for use
Labeled indications
Adults
•
Treatment of allergic rhinitis (seasonal or perennial)
Safety risks
Contraindications
Hypersensitivity to fluticasone furoate or its components
Warnings and precautions
Angioedema, allergic contact dermatitis, urticaria
•
Use caution in patients with hypersensitivity to fluticasone.
Cushing's syndrome, adrenal insufficiency
•
Use caution in patients on high dosages or at the regular dosage in susceptible individuals.
Exacerbation of tuberculosis, herpes simplex ocular infection
•
Use caution in patients with existing tuberculosis; fungal, bacterial, viral, or parasitic infection; ocular herpes simplex.
Glaucoma, cataract
•
Use caution in patients with the long-term administration of ICSs, including fluticasone furoate.
Growth delay
•
Use caution in pediatric patients.
Nosebleed, nasal ulcers, nasal septum perforation
•
Maintain a high level of suspicion, as fluticasone has been associated with nasal septal perforation, nose bleeds and nasal ulcers.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Any modality
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Any severity
•
Use with caution. Monitor serum concentrations.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B3
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals. Monitor neonates for signs of hypoadrenalism. Pregnant women with asthma should be closely monitored to maintain optimal asthma control.
•
There is insufficient data on use in pregnancy.
Breastfeeding
Acceptable for use during breastfeeding.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
•
Bronchitis, headache
Common 1-10%
•
Influenza virus infection, back pain, cough, fever, throat pain, upper respiratory tract infections
Unknown frequency
•
Adrenal insufficiency, anaphylaxis, angioedema, bronchospasm, cataract, Cushing's syndrome, ↓ bone mineral density, delayed wound healing, diabetes mellitus type 2, glaucoma, growth restriction, immunosuppression, ↑ intraocular pressure, nasopharyngitis, osteoporosis, pneumonia, skin rash, urticaria
Interactions
Drug(s)
Check Interactions
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