Chlordiazepoxide
Class
Anxiolytics
Subclass
Benzodiazepines
Substance name
chlordiazePOXIDE hydrochloride
Brand names
Librax®, Librium®
Common formulations
Capsule
Dosage and administration
Adults patients
Symptomatic relief
Alcohol withdrawal syndrome
Anxiety • Mild-to-moderate
Anxiety • Severe
Treatment
Anxiety disorders • Mild-to-moderate
Anxiety disorders • Severe
Other off-label uses
Indications for use
Labeled indications
Adults
Off-label indications
Adults
Safety risks
Contraindications
Acute angle-closure glaucoma
A known or suspected hypersensitivity to chlordiazepoxide
Pre-existing respiratory insufficiency
Prostatic hypertrophy or benign bladder neck obstruction (bladder obstruction)
Warnings and precautions
Angioedema
Depression
Drug abuse
Exacerbation of porphyria
Myasthenia gravis
Respiratory depression
Seizures
Specific populations
Renal impairment
eGFR 20-50 mL/min/1.73 m²
eGFR 10-20 mL/min/1.73 m²
eGFR < 10 mL/min/1.73 m²
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Any severity
Substantial chronic alcohol consumption
Pregnancy and breastfeeding
Pregnancy
First trimester • Australia Category: C
Second trimester • Australia Category: C
Third trimester • Australia Category: C
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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