Bupropion hydrochloride SR
Class
Antidepressants
Subclass
Norepinephrine-dopamine reuptake inhibitors
Substance name
buPROPion SR
Brand names
Wellbutrin SR®, Zyban®
Common formulations
Film-coated tablet, Tablet
See also
Bupropion hydrochloride
Bupropion hydrochloride XL (Forfivo XL®, Wellbutrin XL®)
Bupropion hydrobromide ER (Aplenzin®)
Dosage and administration
Adults patients
Symptomatic relief
Neuropathic pain • Off-label
Treatment
Major depressive disorder
ADHD • Off-label
Amphetamine use disorder • Off-label
Cocaine use disorder • Off-label
Drug-induced sexual dysfunction in females • SSRIs • Off-label
Facilitation
Facilitation of smoking cessation • Off-label
Other off-label uses
Indications for use
Labeled indications
Adults
Off-label indications
Adults
Safety risks
Boxed warnings
Suicidal ideation
Contraindications
Hypersensitivity to bupropion or its components
Abrupt discontinuation of alcohol, benzodiazepines, barbiturates, or antiepileptic drugs
Concomitant use of MAOIs
Warnings and precautions
Acute angle-closure glaucoma
Delusions, hallucinations, psychosis, paranoid ideation
Hypertension
Manic or mixed episodes
Seizure
Specific populations
Renal impairment
CrCl > 60 mL/min
CrCl 15-60 mL/min
CrCl < 15 mL/min
Renal replacement therapy
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Child-Pugh A (mild)
Child-Pugh B (moderate)
Child-Pugh C (severe)
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B2
Breastfeeding
Consider alternative agents that may be safer.
Very low levels in breastfed infants (< 5%).
May potentially cause adverse effects in breastfed infants.
Some adverse effects on lactation reported.
Adverse reactions
Very common > 10%
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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