Atomoxetine
Class
Antidepressants
Subclass
Serotonin-norepinephrine reuptake inhibitors
Substance name
Atomoxetine hydrochloride
Brand names
Strattera®
Common formulations
Capsule
Dosage and administration
Adults patients
ADHD
Social anxiety disorder in patients with ADHD • Off-label
Other off-label uses
Indications for use
Labeled indications
Adults
Children
Off-label indications
Adults
Safety risks
Boxed warnings
Suicidal ideation
Contraindications
Hypersensitivity to atomoxetine or its components
Angle-closure glaucoma
Pheochromocytoma
Severe cardiovascular disorders
Concomitant use of MAOIs
Warnings and precautions
Aggressive behavior
Aggressive behavior, hostility
Cardiovascular mortality, hypertension, tachycardia
Growth delay
Hepatotoxicity
Increased BP, increased HR
Increased serum atomoxetine levels
Manic or mixed episodes
Orthostatic hypotension, syncope
Priapism
Psychosis, mania
Urinary retention, UTI
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
Renal replacement therapy
Any modality
Hepatic impairment
Child-Pugh A (mild)
Child-Pugh B (moderate)
Child-Pugh C (severe)
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B3
Breastfeeding
Consider alternative agents that may be safer.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
Common 1-10%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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