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Splenomegaly

Guidelines

Key sources

The following summarized guidelines for the evaluation and management of splenomegaly are prepared by our editorial team based on guidelines from the American Academy of Family Physicians (AAFP 2021).
1

Diagnostic investigations

Initial assessment: as per AAFP 2021 guidelines, elicit a history of liver disease and alcohol use in patients presenting with splenomegaly in the US.
B
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  • Abdominal ultrasound

Nonpharmacologic interventions

Exercise restriction: as per AAFP 2021 guidelines, restrict sports participation for patients with infectious mononucleosis for at least 21-31 days after symptom onset.
B

Preventative measures

Immunizations: as per AAFP 2021 guidelines, provide vaccinations against encapsulated organisms in functionally asplenic patients to prevent infection.
B