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T-cell/natural killer-cell lymphoma

Key sources
The following summarized guidelines for the evaluation and management of T-cell/natural killer-cell lymphoma are prepared by our editorial team based on guidelines from the British Society for Haematology (BSH 2022).


1.Diagnostic investigations

Imaging for staging: obtain staging and end-of-treatment PET-CT for all non-leukemic peripheral T-cell lymphoma types.
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2.Diagnostic procedures

Bone marrow biopsy
Perform bone marrow biopsy for accurate staging in patients with nodal peripheral T-cell lymphoma.
Perform re-biopsy at relapse where clinically feasible.

3.Medical management

General principles
Discuss all cases of peripheral T-cell lymphoma with a regional lymphoma multidisciplinary team, including expert pathology review and clinical management recommendations. Discuss cases of patients aged < 25 years with a teenage and young adult specialist.
Offer enrollment in a clinical trial, wherever possible, in all patients with peripheral T-cell lymphoma, both untreated and relapsed/refractory.

More topics in this section

  • Management of T-cell prolymphocytic leukemia

  • Management of large granular lymphocytic leukemia

  • Management of adult T-cell leukemia/lymphoma

  • Management of anaplastic large cell lymphoma

  • Management of peripheral T-cell lymphoma NOS/angioimmunoblastic T-cell lymphoma

  • Management of extranodal NK/T-cell lymphoma/aggressive NK-cell leukemia

  • Management of aggressive intestinal T-cell lymphoma

  • Management of hepatosplenic T-cell lymphoma