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Uterine septum

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The following summarized guidelines for the evaluation and management of uterine septum are prepared by our editorial team based on guidelines from the American Society for Reproductive Medicine (ASRM 2016).


1.Diagnostic investigations

Diagnostic imaging: obtain diagnostic imaging (3D ultrasound, sonohysterography, or MRI) with or without hysteroscopy, as first-line investigations, rather than laparoscopy/hysteroscopy.
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2.Medical management

Danazol: insufficient evidence to recommend for or against the use of danazol or GnRH agonists to thin the endometrium prior to hysteroscopic septum incision.

3.Surgical interventions

Hysteroscopic septum incision: several observational studies indicate that hysteroscopic septum incision is associated with improved clinical pregnancy rates in women with infertility.
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  • Uterine septum incision

  • Postoperative care

4.Patient education

Effect on fertility: recognize that studies assessing the association between infertility and uterine septum are comprised of principally small descriptive studies that have inconsistent associations.
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  • Effect on pregnancy