Home

Search

Pathway AI

Account ⋅ Sign Out

Table of contents

Ascites

Definition
Ascites is a pathologic accumulation of fluid within the peritoneal cavity that usually develops as a result of liver disease, congestive HF, or nephrotic syndrome.
1
Pathophysiology
Ascites is most frequently caused by portal hypertension occurring in the setting of cirrhosis. Other causes are broadly divided into pre-hepatic (portal vein thrombosis, lymphoma, abdominal lymphatic injury or obstruction, bowel perforation, renal failure, pancreatitis, peritoneal tuberculosis or malignancy with peritoneal implants) and post-hepatic (congestive HF, constrictive pericarditis, Budd-Chiari syndrome, and stricture/web formation in the IVC) causes.
2
Disease course
Ascites causes clinical manifestations of abdominal distention, abdominal fullness, discomfort, shortness of breath, early satiation, and a sense of reduced mobility.
2
Prognosis and risk of recurrence
Ascites is associated with a 1-year mortality of 40%. Refractory ascites has a median survival rate of 6 months.
2
Key sources
The following summarized guidelines for the evaluation and management of ascites are prepared by our editorial team based on guidelines from the American Gastroenterological Association (AGA 2023), the American Association for the Study of Liver Diseases (AASLD 2021; 2014), the British Association for the Study of the Liver (BASL/BSG 2021), and the European Association for the Study of the Liver (EASL 2018).
1
2
3
4
5
6
7

Guidelines

1.Diagnostic investigations

Initial evaluation
Obtain the following as part of the initial evaluation of patients with ascites:
history and physical examination
abdominal ultrasound
laboratory assessment of liver and renal functions, serum and urine electrolytes
ascitic fluid analysis
Use contrast media cautiously and implement appropriate preventive measures for renal impairment,
B
although the use of contrast media does not appear to be associated with an increased risk of renal impairment in patients with ascites and preserved renal function.
B
Create free account

2.Diagnostic procedures

Diagnostic paracentesis: as per AASLD 2021 guidelines, perform diagnostic paracentesis in all patients with new-onset ascites accessible for sampling.
E
Show 5 more

3.Medical management

General principles
Control and treat gastrointestinal hemorrhage, renal impairment, hepatic encephalopathy, hyponatremia, or alterations in serum potassium concentration before initiating diuretic therapy. Be cautious when initiating diuretic therapy and obtain frequent clinical and biochemical assessments.
B
Identify and treat etiological factors in patients with decompensated cirrhosis, particularly alcohol consumption and hepatitis B or C virus infection.
B

More topics in this section

  • Diuretic therapy

  • Intravenous albumin

  • Other agents

  • Medications to avoid

  • Management of hyponatremia

4.Nonpharmacologic interventions

Salt restriction: as per AASLD 2021 guidelines, advise moderate sodium restriction (2 g or 90 mmol/day) in patients with cirrhosis and grade 2 ascites.
E

More topics in this section

  • Fluid restriction

  • Physical activity

5.Therapeutic procedures

Therapeutic paracentesis: as per AASLD 2021 guidelines, perform large-volume paracentesis as first-line therapy in patients with grade 3 ascites. Advise sodium restriction and initiate diuretics after paracentesis.
E

More topics in this section

  • TIPS

  • Implantable peritoneal pump

6.Surgical interventions

Liver transplantation: as per AASLD 2021 guidelines, consider referring patients with grade 2 or 3 ascites for evaluation for liver transplantation.
E

More topics in this section

  • Elective hernia repair

7.Specific circumstances

Pediatric patients: obtain a comprehensive evaluation of clinical history, physical examination, and diagnostic testing including abdominal ultrasound for the diagnosis of ascites and its cause in pediatric patients.
E
Show 6 more

More topics in this section

  • Patients with bacterascites

  • Patients with hepatic hydrothorax

8.Follow-up and surveillance

Serial clinical and laboratory assessment: as per AASLD 2021 guidelines, monitor body weight and serum creatinine and sodium regularly to assess response and to detect the development of adverse effects in patients receiving diuretics.
E

More topics in this section

  • Post-TIPS care

  • Management of inadequate response

  • Management of refractory ascites