Home

Loading...

Table of contents

Non-epithelial ovarian cancer

Guidelines

Key sources

The following summarized guidelines for the evaluation and management of non-epithelial ovarian cancer are prepared by our editorial team based on guidelines from the European Society of Medical Oncology (ESMO 2018) and the U.S. Preventive Services Task Force (USPSTF 2018). ...
Show more

Screening and diagnosis

Indications for screening: as per USPSTF 2018 guidelines, avoid screening for ovarian cancer in asymptomatic females.
D
Create free account

Diagnostic investigations

Diagnostic imaging: as per ESMO 2018 guidelines, obtain pelvic ultrasound, abdominopelvic CT, CXR, and PET in the diagnostic work-up of selected patients with non-epithelial ovarian cancer (germ cell tumor).
B

More topics in this section

  • Laboratory testing

Diagnostic procedures

Biopsy and pathology: as per ESMO 2018 guidelines, perform infracolicomentectomy, a biopsy of the diaphragmatic peritoneum, paracolic gutters, pelvic peritoneum, and peritoneal washings (macroscopic stage I disease) for staging.
Show 3 more

More topics in this section

  • Retroperitoneal lymph node assessment

  • Endometrial curettage

Medical management

General principles
As per ESMO 2018 guidelines:
Attempt treating patients with small cell carcinoma of the ovary, hypercalcemic type in a more homogeneous way through national and international networks.
B
Offer a multimodal treatment approach including chemotherapy
B
, radical surgery
B
, high-dose chemotherapy
B
and radiotherapy in patients with all stages of small cell carcinoma of the ovary, hypercalcemic type.
B

More topics in this section

  • Adjuvant chemotherapy (indications)

  • Adjuvant chemotherapy (regimens)

  • Hormone replacement therapy

Therapeutic procedures

Pelvic radiotherapy: as per ESMO 2018 guidelines, consider offering postoperative pelvic radiotherapy, either concurrently or sequentially to high-dose chemotherapy and ASCT. in patients with early or advanced small cell carcinoma of the ovary, hypercalcemic type.
C

Surgical interventions

General principles: as per ESMO 2018 guidelines, use an open surgical approach or, in selected cases, laparoscopic and robotic approaches, thereby avoiding tumor rupture during surgery.
Show 6 more

More topics in this section

  • Conservative fertility-sparing surgery

  • Abdominal hysterectomy and bilateral salpingo-oophorectomy

Specific circumstances

Patients wishing to preserve fertility: as per ESMO 2018 guidelines, consider offering oocyte cryopreservation in patients scheduled to receive chemotherapy.
C
Show 2 more

Follow-up and surveillance

Assessment of treatment response: as per ESMO 2018 guidelines, recognize that serum tumor markers (hCG, α-fetoprotein, LDH, CA-125, and inhibin B) can correlate with tumor response during chemotherapy.
B
Show 2 more

More topics in this section

  • Follow-up