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Focal segmental glomerulosclerosis


Key sources

The following summarized guidelines for the evaluation and management of focal segmental glomerulosclerosis are prepared by our editorial team based on guidelines from the Kidney Disease: Improving Global Outcomes Foundation (KDIGO 2021) and the Japanese Society of Nephrology (JSN 2016). ...
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Diagnostic investigations

Initial evaluation
As per KDIGO 2021 guidelines:
Evaluate for secondary causes in adult patients with FSGS without nephrotic syndrome.
Consider referring selected patients with FSGS to specialized centers for genetic testing.
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Medical management

Corticosteroids: as per KDIGO 2021 guidelines, initiate high-dose oral corticosteroids as first-line immunosuppressive treatment in patients with primary FSGS.
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  • Immunosuppressants

Follow-up and surveillance

Management of relapse: as per KDIGO 2021 guidelines, consider managing adult patients with previous corticosteroid-sensitive primary FSGS experiencing a relapse as adult patients with relapsing minimal change disease.