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Lambert-Eaton myasthenic syndrome

What's new

Added 2023 DGN, 2023 ACCP, 2012 AAN, and 2010 EFNS guidelines for the diagnosis and management of Lambert-Eaton myasthenic syndrome.

Guidelines

Key sources

The following summarized guidelines for the evaluation and management of Lambert-Eaton myasthenic syndrome are prepared by our editorial team based on guidelines from the American College of Chest Physicians (ACCP 2023), the German Neurological Society (DGN 2023), the American Academy of Neurology (AAN 2012), and the European Federation of Neurological Societies (EFNS 2010,2008). ...
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Diagnostic investigations

Respiratory evaluation: as per ACCP 2023 guidelines, obtain pulmonary function testing to assist with management decisions in patients with neuromuscular disease at risk for respiratory complications.
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Respiratory support

Airway clearance: as per ACCP 2023 guidelines, consider offering glossopharyngeal breathing for lung volume recruitment and airway clearance in patients with hypoventilation.
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More topics in this section

  • Noninvasive ventilation

  • Invasive ventilation

Medical management

Symptomatic treatment: as per DGN 2023 guidelines, offer amifampridine and pyridostigmine for symptomatic therapy in patients with LEMS.
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More topics in this section

  • Immunosuppressants

  • IVIG

Therapeutic procedures

Plasmapheresis/immunoadsorption: as per DGN 2023 guidelines, perform plasmapheresis/immunoadsorption if appropriate for the management of crisis worsening.
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Specific circumstances

Patients with paraneoplastic Lambert-Eaton syndrome: as per DGN 2023 guidelines, treat the primary tumor in patients with paraneoplastic LEMS as usual.