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Antimicrobial-resistant Gram-negative infections

Key sources
The following summarized guidelines for the management of antimicrobial-resistantGram -negative infections are prepared by our editorial team based on guidelines from the Infectious Diseases Society of America (IDSA 2023) and the European Society for Microbiology and Infectious Diseases (ESCMID 2021; 2019).
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Guidelines

1.Medical management

General principles: use optimal antibiotic dosing schemes with attention to side effects, especially with the old antibiotics (polymyxins and aminoglycosides).
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More topics in this section

  • Management of Enterobacterales infections (ESBL-producing)

  • Management of Enterobacterales infections (AmpC beta-lactamase-producing)

  • Management of Enterobacterales infections (third-generation cephalosporin-resistant)

  • Management of Enterobacterales infections (carbapenem-resistant)

  • Management of P. aeruginosa infections (carbapenem-resistant)

  • Management of P. aeruginosa infections (with difficult-to-treat resistance)

  • Management of A. baumannii infections (carbapenem-resistant)

  • Management of S. maltophilia infections

2.Preventative measures

Decolonization of multidrug-resistant Gram-negative bacteria carriers: do not offer routine decolonization in third-generation cephalosporin-resistant or carbapenem-resistant Enterobacterales carriers.
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