Table of contents

Relapsing polychondritis


Key sources

The following summarized guidelines for the evaluation and management of relapsing polychondritis are prepared by our editorial team based on guidelines from the American College of Rheumatology (ACR 2023), the European League Against Rheumatism (EULAR 2022), and the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET 2018). ...
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Diagnostic investigations

Pretreatment evaluation: as per EULAR 2022 guidelines, screen for HBV infection in all patients eligible for treatment with conventional synthetic, biological, or targeted synthetic DMARDs, immunosuppressants, or corticosteroids (according to dose and duration).
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Medical management

General principles: as per ERN ReCONNET 2018 guidelines, take into account disease severity and patient individual characteristics to decide on the treatment strategy in patients with RP, and contact an RP center when appropriate.

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  • Management of auricular or nasal chondritis

  • Management of peristernal chondritis

  • Management of tracheal chondritis

  • Management of articular involvement

  • Management of cutaneous involvement

  • Management of cardiac involvement

  • Management of ocular involvement

  • Management of audiovestibular involvement

  • Management of nervous system involvement

  • Management of renal involvement

Preventative measures

Routine immunizations: as per ACR 2023 guidelines, consider offering high-dose or adjuvanted influenza vaccination, rather than regular-dose influenza vaccination, in ≥ 65 years old patients with rheumatic or musculoskeletal diseases and in 18-65 years old patients with rheumatic or musculoskeletal diseases on immunosuppressive medications.
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  • Prophylaxis for P. jirovecii pneumonia