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Deprescribing proton pump inhibitors

Guidelines

Key sources

The following summarized guidelines for the management of deprescribing proton pump inhibitors are prepared by our editorial team based on guidelines from the American Gastroenterological Association (AGA 2022) and the College of Family Physicians of Canada (CFPC 2017).
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Medical management

Indications for discontinuation: as per AGA 2022 guidelines, consider discontinuing PPIs in all patients without a definitive indication for chronic use.
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  • Considerations for discontinuation

Patient education

General counseling: as per AGA 2022 guidelines, counsel patients discontinuing long-term PPI therapy that they may develop transient upper gastrointestinal symptoms due to rebound acid hypersecretion.
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Follow-up and surveillance

Monitoring for indications: as per AGA 2022 guidelines, obtain a regular review (by the patient's primary care provider) of the ongoing indications for use and document that indication in all patients taking a PPI.
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