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The Sodium Correction for Hyperglycemia calculator takes inputs of measured sodium and blood glucose levels to compute corrected sodium levels using three different formulas: Katz, Hillier, and Adrogué-Madias. These corrections are necessary because hyperglycemia can lead to artificially low sodium measurements, and adjusting for this helps in more accurate clinical assessments.

Inputs:
1. Measured Sodium: This is the serum sodium level provided by the user, which can be in units of mEq/L or mmol/L. The acceptable range is 100 to 180 for both units.
2. Blood Glucose: The glucose level provided by the user, which can be in units of mg/dL or mmol/L. The acceptable range is 70 to 1000 mg/dL or 3.9 to 55.5 mmol/L.

Computation:
1. If the blood glucose input is in mmol/L, it needs to be converted to mg/dL using the conversion factor (1 mmol/L = 18.02 mg/dL).
2. The calculator applies the following formulas to compute corrected sodium levels:

   - Corrected Sodium (Katz): `measuredSodium + 0.016 * (glucose - 100)`
   - Corrected Sodium (Hillier): `measuredSodium + 0.024 * (glucose - 100)`
   - Corrected Sodium (Adrogué-Madias): `measuredSodium + 0.02 * (glucose - 100)`

3. Each of these corrected sodium values is rounded to the nearest integer to provide a precise reading in units of mEq/L.

Outputs:
1. Corrected Sodium (Katz): The adjusted sodium level using the Katz formula, rounded to the nearest integer, within the range of 100 to 200 mEq/L.
2. Corrected Sodium (Hillier): The adjusted sodium level using the Hillier formula, also rounded, within the range of 100 to 200 mEq/L.
3. Corrected Sodium (Adrogué-Madias): The adjusted sodium level using the Adrogué-Madias formula, rounded similarly, within the range of 100 to 200 mEq/L.

Interpretation:
The different formulas account for varying perspectives on how hyperglycemia affects sodium levels. The Katz correction typically provides a more conservative correction, while the Hillier correction is more aggressive. The Adrogué-Madias correction falls between the two. Clinicians can interpret these corrected sodium values to assess the severity of hypernatremia in hyperglycemic patients more accurately, thereby guiding appropriate clinical interventions.

The Sodium Correction for Hyperglycemia calculator adjusts the measured serum sodium levels to account for hyperglycemia. Hyperglycemia causes a dilutional hyponatremia due to the osmotic effect of glucose, pulling water from intracellular to extracellular compartments. This correction is vital for accurately assessing a patient’s sodium status in the presence of elevated blood glucose levels.

In-hospital hyperglycemia

Guidelines

Key sources