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TNM classification for bone cancer (appendicular skeleton, trunk, skull, and facial bones)

Tumor classification
Tx: Primary tumor cannot be assessed
T0: No evidence of primary tumor
T1: Tumor ≤ 8 cm in greatest dimension
T2: Tumor > 8 cm in greatest dimension
T3: Discontinuous tumors in the primary bone site
Lymph node classification
Nx: Regional lymph nodes cannot be assessed
N0: No regional lymph node metastasis
N1: Regional lymph nodes metastases present
Distant metastasis
M0: No distant metastasis
M1a: Metastasis confined to lung
M1b: Metastases in bones or other distant sites
Histologic grade
Gx: Grade cannot be assessed
G1: Well differentiated
G2: Moderately differentiated
G3: Poorly differentiated
G4: Undifferentiated
Stage cannot be fully assessed
Reference
Amin, M.B., Edge et al. AJCC Cancer Staging Manual. AJCC. 2017.
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