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Simplified Livneh diagnostic criteria for familial Mediterranean fever

Calculator

When to use

Major criteria

Typical attacks of generalized peritonitis

Typical attacks of unilateral pleuritis or pericarditis

Typical attacks of monoarthritis hip, knee, ankle)

Typical attacks of fever alone

Incomplete abdominal attacks

Minor criteria

Incomplete thoracic or articular attacks, or both

Exertional leg pain

Favorable response to colchicine

Calculation

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The Simplified Livneh Diagnostic Criteria for Familial Mediterranean Fever (FMF) is a clinical calculator used to diagnose Familial Mediterranean Fever, a hereditary inflammatory disorder. This calculator is applicable to individuals of all ages who present with recurrent febrile episodes and are suspected of having FMF, particularly those of Mediterranean descent, including Armenians, Arabs, Turks, and Jews. The Simplified Livneh Diagnostic Criteria for FMF is clinically useful in identifying patients with FMF, which can help guide appropriate treatment and management strategies. It takes into account factors such as the frequency and duration of fever episodes, presence of specific symptoms like abdominal pain or arthritis, response to colchicine treatment, and family history of FMF. Exclusion criteria for the use of this calculator include the presence of other conditions that could explain the patient's symptoms, such as infections, malignancies, or other rheumatic diseases. Additionally, it may not be as accurate in populations where FMF is less common.

Reference

A Livneh, P Langevitz, D Zemer et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997 Oct;40(10):1879-85.

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